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Drug interactions

Video: Drug Interactions: What You Should Know FD

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Drug-drug interactions occur when two or more drugs react with each other. This drug-drug interaction may cause you to experience an unexpected side effect. For example, mixing a drug you take to. Use WebMD's Drug Interaction Checker tool to find and identify potentially harmful and unsafe combinations of prescription medications by entering two or more drugs in question The drug interactions checker will check for interactions between the drugs you enter, any possible food or disease interactions and pregnancy / breastfeeding warnings. Getting Started. Type in a drug name and then select your medicine from the list. Add as many prescription drugs or OTC drugs as you want to

Drug Interaction Checker. Use the search field above to look up prescription or OTC drugs, and herbal supplements; Add a full drug regimen and view interactions Drug | Interaction Checker; Check for Drug Interactions Our drug interaction checker provides the guidance you need for a further conversation with your pharmacist or health care provider.* Add Medications. Generate Report. Start Over Step 1: Add CVS Pharmacy prescriptions (optional).. CYTOCHROME P450 DRUG INTERACTION TABLE. Note: If you are on a Mobile device, please go to the Search area to interact more easily. Overview. This table is designed as a hypothesis testing, teaching and reference tool for physicians and researchers interested in drug interactions that are the result of competition for, or effects on the human cytochrome P450 system Drug-drug interaction checkers are also useful in evaluating potential interactions and can be used to check individual drugs or products against one another. Some drug interactions can be managed by stopping one of the culprit medications for a period of time or by taking each medication at a different time of day

Drug Interactions. Pharmacy Author: Omudhome Ogbru, PharmD Medical and Pharmacy Editor:Jay W. Marks, MD Drug interactions overview. Whenever two or more drugs are being taken, there is a chance that there will be an interaction among the drugs Drug Interaction Checker. This tool uses the following resources provided by the US National Library of Medicine: ONCHigh is a list of high-priority drug-drug interactions derived by a panel of experts and contained in a JAMIA article. DrugBank contains the drug-drug interactions contained in the DrugBank database

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Drug Interactions Checker - Medicine

Drug-Drug Interaction Resources. HIV and Hepatitis drug interaction information from The University of Liverpool. Covid19 drug interaction information from The University of Liverpool, University of Basel & Radboud UMC. Cancer drug interaction information from Radboud UMC & The University of Liverpool Drug-drug interactions (DDIs) occur when one drug interferes with the pharmacological activity of another [58]. These interactions can result in decreased effectiveness and/or increased toxicity. Additionally they may result in the development of ADRs, morbidity, hospitalizations and death [59]. DDIs constitute only a small proportion of ADRs. Warfarin drug interactions. Severity - Major: The effects are potentially life-threatening or capable of causing permanent damage. Severity - Moderate: The effects may cause deterioration in a patient's clinical status. Additional treatment, hospitalization, or an extended hospital stay may be necessary. Severity - Minimal: The effects are. Potential drug interactions. Look for the grapefruit warning. Although studies are still ongoing to determine potential interactions between CBD and specific medications,. Drug Interaction API. The Interaction API is a web service for accessing drug-drug interactions. Currently, the API uses two sources for its interaction information - ONCHigh and DrugBank. ONCHigh is a list of high-priority drug-drug interactions derived by a panel of experts and contained in a JAMIA article

Drug Interactions Checker - Medscape Drug Reference Databas

How drug interactions happen. The term drug interactions is somewhat misleading. Drugs don't combine in the body to produce chemical reactions. Instead, a drug, supplement, or food may affect how long a medication stays in the body, often by stimulating or inhibiting the production of specific enzymes in the liver or intestine Drug interactions should be considered as a possible cause of any unexpected problems. When unexpected clinical responses occur, prescribers should determine serum concentrations of selected drugs being taken, consult the literature or an expert in drug interactions, and adjust the dosage until the desired effect is produced Theanine is an amino acid found in tea. It is also found in some mushrooms. Theanine comes in two forms - L-theanine and D-theanine. L-theanine is the form most commonly found in tea and. A series of mini-lectures on topics including pharmacology, hepatitis and drug-drug interactions Prescribing Resources. Interaction tables, treatment selectors, clinical prescribing resources, and pharmacokinetic fact sheets Twitter @hepinteractions. Follow us on Twitter for interaction news and for the latest additions and changes to the.

This service is primarily for users who need to use the interaction checker service in an older browser. Ideally, you should try to upgrade your browser to the latest version in order to use our full featured interaction checker. However, if that is not possible or if local settings are preventing the checker displaying correctly, you can still. Drug-drug interactions occur when two or more drugs alter each other's effects or increase the chances of side effects. The drugs may be taken for the same disease or two different diseases. drug interaction: [ in″ter-ak´shun ] 1. the quality, state, or process of (two or more things) acting on each other. 2. reciprocal actions or influences among people, such as mother-child, husband-wife, client-nurse, or parent-teacher. drug interaction see drug interaction . impaired social interaction a nursing diagnosis accepted by the North.

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Drug Interaction Checker CVS Pharmac

Pharmacodynamic interactions are drug-drug interactions that involve the direct effects of the interacting drugs and a change in a patient's response to the drugs [Trevor, et al. 2015]. Pharmacodynamic interactions may involve pharmacologic receptors, and drugs may be agonists or antagonists of other drugs Drug-drug interactions occur when one drug interacts with another. Certain drugs are more prone to interactions than others. For example, warfarin is an anticoagulant used to help prevent blood clots Drug interactions involve combinations of a medication with other substances that alter the medication's effect on the body. This can cause the medication to be less or more potent than intended. Helpful tool: Drug Interaction Checker. Enter any list of prescription drugs, over-the-counter drugs, herbals and supplements to see how they interact with each other and with other substances. But be sure to check with your physician and talk with your pharmacist. Check and search medical symptoms and causes online The following are drug interactions for which monitoring is recommended: Drugs Metabolized by CYP2D6. Since Myrbetriq is a moderate CYP2D6 inhibitor, the systemic exposure to CYP2D6 substrates such as metoprolol and desipramine is increased when co‑administered with Myrbetriq

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Drug interactions with the following herbal supplements are unlikely or very limited: black cohosh, cranberry, ginkgo, American ginseng, milk thistle, saw palmetto, and valerian. With specific. Yet a 2013 Consumer Reports Survey found that only 28 percent of people taking dietary supplements and prescription drugs together checked with a pharmacist about potential interactions (when a.

While some vaccines such as the shingles vaccine have been known to interact negatively with other medications, experts have yet to find any negative drug interactions with the COVID-19 vaccine. Find out more in this guide from GoodRx The potential dangers of the concomitant administration of 2 or more drugs with anticholinergic (antimuscarinic) properties have been known for a long time. 1 These dangers are pharmacodynamic drug interactions resulting from additive anticholinergic effects—although occasionally there may be a pharmacokinetic mechanism acting simultaneously. Over the past decade, efforts have been made to. Other Possible Interactions: Another compound found in cinnamon is cinnamaldehyde. This agent inhibits the enzyme CYP 2A6 and consequently can interfere with the metabolism of nicotine ( Drug Metabolism & Disposition, April 2016 ). We trust, however, that your husband is not smoking cigarettes or chewing nicotine gum One of the most well known food-drug interactions is grapefruit juice and the HMG-CoA reductase inhibitors, more commonly known as statins. Grapefruit juice, in large quantities (32 oz. or more per day), can inhibit the cytochrome P450 3A4 (CYP3A4) enzyme and increase blood levels of drugs metabolized by this pathway, such as certain statin.

Drug Interaction Checker DrugBank Onlin

  1. Drug-drug interactions (DDIs) are one of the commonest causes of ADRs and we reported that these manifestations are commons in the elderly due to poly-therapy.[4,5,6,7] In fact, poly-therapy increases the complexity of therapeutic management and thereby the risk of clinically relevant drug interactions, which can induce the development of ADRs.
  2. ation with active pharmaceutical agents are among the safety concerns about dietary and herbal supplements. Although there is a widespread public perception that herbs and botanical products in dietary supplements are safe, research has demonstrated that these products carry the same dangers as other pharmacologically active.
  3. e. Combining both of those drugs can make the patient even sleepier, slow their reactions and make it dangerous to drive or operate machinery
  4. A drug interaction is a reaction between two (or more) drugs or between a drug and a food, beverage, or supplement. Taking a drug while having certain medical conditions can also cause a drug interaction. For example, taking a nasal decongestant if you have high blood pressure may cause an unwanted reaction
  5. The Drug Interaction Database (referred to as DIDB), part of UW Drug Interaction Solutions, is designed to support research and regulatory scientists in their decision-making when evaluating PK-based drug interactions and drug safety. The database has the largest manually curated collection of qualitative and quantitative human in vitro and in.
  6. CYTOCHROME P450 DRUG INTERACTION TABLE - Drug Interactions
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This food and drug interaction can be a concern, says Shiew Mei Huang, PhD, of the U.S. Food and Drug Administration. The FDA has required that some prescription and over-the-counter (OTC) drugs. Results: The main interactions between COVID-19 drugs and antipsychotics are the risk of QT-prolongation and TdP, and cytochromes P450 interactions. Remdesivir, baricinitib, and anakinra can be used concomitantly with antipsychotics without risk of drug-drug interaction (except for hematological risk with clozapine and baricinitib) Recognizing drug interactions is a daily challenge for family physicians, and remembering all potential interactions has become virtually impossible. Most pharmacies have drug-interaction software. Turmeric has been known to interact with several types of drugs taken for common ailments such as diabetes, pain, blood clotting and many more. The level of interactions may vary depending on the dosage of both the drug and the herb. Depending on the interaction, turmeric may increase or decrease the effectiveness of the drug taken along with it

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  1. Piperine Drug Interactions. July 28, 2017. John R. Horn, PharmD, FCCP, Philip D. Hansten, PharmD. Pharmacy Times, July 2017 Digestive Health, Volume 83, Issue 7. Piperine is a major alkaloid found in black pepper (piper nigrum), and the alkaloid is used as an herbal product for its purported anti-inflammatory, antioxidant, and antitumor properties
  2. The issue of herb-drug interactions looms large over the practice of herbal medicine. Up to now there have been very few incidents recorded of herb-drug interactions, but since the first such reports emerged a decade ago, a concern has been raised: that we know so little about herbs and their potential for interaction with drugs that these incidents could be just th
  3. Drug Interactions Cytochrome P450 Enzymes 11 THC is a CYP1A2 inducer. Theoretci ayll T, HC can decrease serum concentrations of clozapine, duloxetine, naproxen c, yclobenzaprine o, lanzapine, haloperidol, and chlorpromazine (Flockhart 2007, Watanabe et al 2007). CBD is a potent inhibitor of CYP3A4 and CYP2D6. As CYP3A
  4. Potential for Herb-Drug Interactions. Goldenseal is a potent inhibitor of both CYP3A4 and CYP2D6 enzyme activity. A 2012 review concluded that that goldenseal's herb-drug interaction risk is high. The CYP enzyme interactions are thought to be due to the two most common isoquinoline alkaloids found in goldenseal, berberine and hydrastine. Efficac

Drug interactions are a common concern with immunosuppressants. 18 Prescription and over-the-counter medications, supplements, and nutraceuticals can have both pharmacodynamic and pharmacokinetic effects on many immunosuppressive agents (Box 15-2) Frequently, interactions can occur with tacrolimus, cyclosporine, sirolimus, and everolimus, which. The mechanism involved in most interactions between cigarette smoking and drugs involves the induction of metabolism. Drugs for which induced metabolism because of cigarette smoking may have clinical consequence include theophylline, caffeine, tacrine, imipramine, haloperidol, pentazocine, propranolol, flecainide and estradiol

Drug Interaction Checker RxIS

Online databases are available to help health professionals evaluate potential drug-drug interactions, at a price. Freely available resources tend to be less reliable, and this highlights the importance of discussing all your medications, including CBD, with your doctor and pharmacist, says Dr. Bemben More potentially serious drug-drug interactions were identified between drugs recommended by guidelines for each of the three index conditions and drugs recommended by the guidelines for the 11 other conditions: 133 drug-drug interactions for drugs recommended in the type 2 diabetes guideline, 89 for depression, and 111 for heart failure

AARP is a nonprofit, nonpartisan organization that empowers people to choose how they live as they age Theoretical Interactions. Chamomile has compounds that inhibit drug-metabolizing enzymes of the human cytochrome P450 family (CYP1A2, CYP2C9, CYP2D6, and CYP3A4). 6  As a result, blood levels for various drugs may be higher than expected when chamomile is consumed This tool may not cover all possible drug interactions. Please check with a physician if you have health questions or concerns. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect. Pill Identifier Tool Quick, Easy, Pill Identification For FDA approved labels included in drug packages, see DailyMed. Herbs and Supplements Browse dietary supplements and herbal remedies to learn about their effectiveness, usual dosage, and drug interactions Drug interactions involving transport are less well understood than drug interactions involving metabolism. Pharmacodynamic drug-drug interactions. Pharmacodynamics is 'what the drug does to the body'. These interactions occur between drugs with additive or opposing effects. The brain is the organ most commonly compromised by.

No known drug interactions have been reported, and no clinically critical drug interactions have been predicted on the basis of in vitro and animal study data (Roche Laboratories Inc., 2009; Daniel, 1999). Limited clinical data are available regarding drug interactions with oral oseltamivir A Drug interaction is an interaction between a drug and some other substance, such as another drug or a certain type of food, which leads to interaction that could manifest as an increase or decrease in the effectiveness or an adverse reaction or a totally new side effect that is not seen with either drug alone that can be severe enough to alter the clinical outcome Drug Interactions. Check COVID/COVID drug interactions. Drug Interactions will be displayed here. Drug combinations may have been assessed either by study or within the product label, or an interaction may have been predicted based on the metabolic profiles of the drugs. These drugs should not be coadministered Drug interactions: The most common side effect is an unpleasant taste. Echinacea can cause liver toxicity. It should be avoided in combination with other medications that can affect the liver such as ketoconazole ( Nizoral , Extina, Xolegel, Kuric ), leflunomide ( Arava ), methotrexate ( Rheumatrex, Trexall ), isoniazid (INH, Nydrazid, Laniazid) Drug Interaction Alerts. The amount of information on drug-drug interactions far exceeds the limits of human memory and recall. The recognition of this limitation has led to the development and use of sophisticated computer software that predicts a portion of the almost limitless permutations of drug-drug interactions. Though helpful in.

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Drug- Food Interactions/ Drug Interaction with Food. The food that you eat can greatly affect the action of certain tablets or 'medications' and result in side effects which can be harmful Three cancer drugs have been added to the interaction checker. Capecitabine, cetuximab and panitumumab are now listed in the interaction checker as cancer drugs and interactions can be found for all the c... May 08, 2018 14:18 Learn how certain drug interactions or an increase in the dose of certain drugs can cause serotonin levels to rise to potentially dangerous levels. COVID-19: Advice, updates and vaccine options COVID-19: Advice, updates and vaccine options We are open for safe in-person care. Learn more. drug interaction. , drug-drug interaction. The combined effect of drugs taken concurrently. The result may be antagonism or synergism and may be lethal in some cases. It is important for the patient, pharmacist, physician, and nurse to be aware of the potential interaction of drugs that are prescribed as well as those that the patient may be. A series of mini-lectures on topics including pharmacology, HIV and drug-drug interactions Prescribing Resources. Interaction tables, treatment selectors, clinical prescribing resources, and pharmacokinetic fact sheets Twitter @hivinteractions. Follow us on Twitter for interaction news and for the latest additions and changes to the website.

Drug Interactions Relevant Regulatory Guidance and

  1. e if the drugs you are taking have any adverse interactions with one another, with over-the-counter drugs, or with your favorite herbs and vita
  2. e) can slow your reactions and make driving a car or operating machinery dangerous
  3. The Horn and Hansten Drug Interaction Probability Scale is included to assess the probability of a causal relationship between a potential drug interaction and a patient event. The Top 100 Drug Interactions is an authoritative drug interaction resource intended for all practitioners that fits in your pocket (8.5 x 5.5 inches)
  4. Drug interactions General considerations A sedative medication may display added sedative effects when used in combination with cannabis. Similarly, cannabis use may augment the adverse effects of drugs with a similar side effect profile.1 It remains to be established whether some drugs interact with cannabis.
  5. Search by Antiretroviral Drug Select an FDA-approved antiretroviral and view interactions with other drugs specified by drug name or drug class, or view all interactions. Search by Interacting Drug Select any drug in the database and view all interactions with FDA-approved antiretrovirals
  6. ation of different drugs. Drug/dietary interactions. No known drug interactions. Assess for poor potassium intake, as hypokalemia may increase the risk of atrial arrhythmias
  7. g visitors about topics such as Drug Interaction, Interaction Checker and Drug Interactions. Join thousands of satisfied visitors who discovered Drug Overdose Symptoms, Mensa and Yoga Meditation Retreat

The Drug Interaction Checker explains the mechanism of each drug interaction, the level of significance of the interaction (major, moderate or minor), and in certain cases, can provide the recommended course of action to manage the interaction. The Drug Interaction Checker will also display any interactions between your chosen drug(s) and food True or False: Drug-Drug Interactions can be beneficial. True. What is the primary route of excretion for most drugs? Renal. What are the primary sites for drug metabolism? (2) Liver Gut. The majority of drug is excreted in the _____, while the remainder is excreted in the _____ A drug-disease interaction is an event in which a drug that is intended for therapeutic use causes some harmful effects in a patient because of a disease or condition that the patient has

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  1. istration of a second can displace it to the non-bound active form.This increases the amount of (unbound) drug available to cause an effect. For example, diazepam displaces phenytoin from plasma proteins, resulting in an increased plasma concentration of free phenytoin and an increased risk of toxicity
  2. Insulin Interactions: An Overview Any medication that affects blood sugar levels may interact with insulin.Some drug interactions may increase blood sugar levels, which is not healthy, but is usually not dangerous right away (although extremely high blood sugar levels can be dangerous if left untreated)
  3. The most common HIV drug interactions involve the liver. Several drugs slow down or speed up the action of liver enzymes. This can cause big changes in the blood levels of other drugs that use the.
  4. e the exact effects of these relationships in the body. A drug is defined as a substance used in the diagnosis, treatment, or prevention of a disease, or component of a medication. There are many dramatic results and problems that may be caused by fooddrug, drug-drug, and alcohol-food-drug.
  5. A drug interaction is a situation in which a substance affects the activity of a drug, i.e. the effects are increased or decreased, or they produce a new effect that neither produces on its own. These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances
  6. K: dietary consistency is the key to maintaining a sustained, stable response during warfarin therapy
  7. istration, 75% of Americans take dietary supplements. A dietary supplement is a vita
Milk of magnesia: Uses, types, risks, and interactions

When certain medications are taken in combination with ginseng, drug interactions may occur that could lead to complications. To help prevent problems, you may want to avoid taking ginseng supplements with blood-thinning medicines, diabetes medications, and medications that are metabolized by enzymes in the liver Drug interactions can make a drug less effective. In some cases, they can make a drug more potent, which can be dangerous. The symptoms of drug interactions vary greatly and range from mild to life threatening. Some common warning signs include feeling sick after taking a medication, not getting the usual results from a medication, or feeling either very tired or very energetic after taking a. Drug-Drug Interaction Mechanisms. Philip Hansten, Pharm.D. John Horn, Pharm.D. Drug-drug interactions are possible whenever a person takes two or more medications concurrently. Recent scientific developments—particularly in the area of cytochrome P450 drug metabolizing enzymes—have revolutionized the study of drug interactions

A food-drug interaction can: prevent a medicine from working the way it should cause a side effect from a medicine to get worse or better cause a new side effect A medicine can also change the way your body uses a food. Any of these changes can be harmful. This guide covers interactions between some common prescription and over-the Find everything you need to know about naproxen (Aleve), including what it is used for, warnings, reviews, side effects, and interactions. Learn more about naproxen (Aleve) at EverydayHealth.com • drug-drug interactions.9 The focus of this document is the drug-drug interaction between rifamycin antibiotics (rifampin, rifabutin, and rifapentine) and four classes of antiretroviral drugs: protease inhibitors, non-nucleoside reverse-transcriptase inhibitors (NNRTI), CCR5-receptor antagonists, and integrase inhibitors.10, 11 Only two o

However, drug interactions can be more appropriately categorized as drug-drug, drug-disease, drug-food, drug-gene, and even drug-laboratory test interactions that can sometimes result in serious sequelae. Among the most harmful drug interactions is one that results in increased toxicity of one or both agents A drug-food interaction occurs when your food and medicine interfere with one another. Interactions can happen with both prescription and over-the-counter medicines. These include antacids, vitamins, and iron pills. Not all medicines are affected by food. Some, though, are affected by what you eat or when you eat it Use these tools to get drug facts for prescriptions, non-prescription medications, vitamins and supplements. Plus, check drug interactions, identify pills and create your personal medicine list Search For Drug Information Search the drug list to find information and videos about how drugs work, common side effects and more Drug-Food Interactions Chart. In the last 5 years, the FDA has collected over $2.5 billion in direct payments from major drug companies including Bristol-Myers, Merck, Johnson & Johnson, Pfizer, GlaxoSmithKline, and Eli Lilly. In exchange for these payments, the FDA has hustled drugs through the approval process, flooding the market with.

Interactions between drugs can be classified as pharmacokinetic and pharmacodynamic. Pharmacodynamic drug-drug interactions are briefly described in another chapter. Here, the focus is on the mechanisms by which drugs interfere with each other's absorption, distribution, metabolism and elimination The UW Drug Interaction Database (DIDB) has the largest manually curated collection of human in vitro and clinical (in vivo) data available. Learn more. More data every day. 00,000 citations with 000,000 entries. 000 NDA/BLAs with 0,000 entries. From all relevant publications (citations) and FDA regulatory documents Viagra Drug Interactions Some of the drugs that can potentially interact with Viagra include cimetidine, ritonavir, and alpha blockers. These drug interactions can change how your body metabolizes the medicines and cause changes in blood pressure, among other things Nexium Drug Interactions There are a number of drugs that may interfere with Nexium. Serious consequences can happen as a result of these interactions, so it's important to tell your healthcare provider about all the medications you take, including over-the-counter medicines, supplements, and vitamins

Amoxicillin-clavulanate potassium labels and packages

Drug Interactions - Drugs - Merck Manuals Consumer Versio

Some drug interactions do not cause problems, but some interactions can be harmful. It is important to discuss the possibility of drug interactions with your health care provider when choosing a new HIV drug combination or when adding or removing any drug from your regimen Herb-Drug Interactions. Herb-drug interactions started appearing in the literature in the 1980s, when reports described the interactions of St. John's wort and grapefruit juice with several prescription drugs. Despite increasing concerns, the term herb-drug interactions was only introduced as a Medical Subject Headings (MeSH) term in 2004 Access our free, comprehensive and user-friendly drug interaction charts Prescribing Resources. Printable interaction tables, interaction summary charts and clinical prescribing resources Twitter @covidDDIs. Follow us on Twitter for interaction news and for the latest additions and changes to the websit 25 Common Caffeine and Drug Interactions. The drug caffeine can sometimes have moderate to severe interactions with other medications a person may be taking.. According to one study, almost 70% of the population of a County in New York was prescribed at least one prescription drug and gives a clue to what is likely happening elsewhere in the USA.. So with caffeine consumption being at an all.

Food-Drug Interaction

Most drug interactions can be managed, he says, so that seriously ill Covid-19 patients can receive the best drug in a lifesaving scenario. But first, doctors need to be aware of the potential. Grapefruit-drug interactions. Some fruit juices and fruits can interact with numerous drugs, in many cases causing adverse effects. The effect was first discovered accidentally, when a test of drug interactions with alcohol used grapefruit juice to hide the taste of the ethanol. The effect is most studied with grapefruit and grapefruit juice. Drugwatch - Trusted Drug & Device Info, Lawsuit & FDA News. 10+ Years of Advocacy. We've educated people about dangerous drugs, faulty medical devices, and lawsuits since 2008. Thousands of People and Families Helped. We give patients a voice, and we've helped more than 12,000 people find legal help

Drug interaction - Wikipedi

Drug-drug interactions are a common problem during drug treatment and give rise to a large number of hospital admissions as a result of medically important, sometimes serious or even fatal adverse events. Drug-drug interactions can also cause partial or complete abolishment of treatment efficacy Prescription Drug Information To help you get a better understanding of some commonly prescribed medications-including their possible side effects, directions on how to take them, and potential drug interactions-we've compiled the following searchable list of drug information Drugs and diseases, such as aspirin and peptic ulcers; Interactions can change the actions of one or both drugs. The drugs might not work, or you could get side effects. Side effects are unwanted effects caused by the drugs. Most are mild, such as a stomach aches or drowsiness, and go away after you stop taking the drug. Others can be more serious Drug interactions may develop either through pharmacokinetic or pharmacodynamic mechanisms. Pharmacodynamic interactions. These are interactions between drugs which have similar or antagonistic pharmacological effects or side-effects. They might be due to competition at receptor sites, or occur between drugs acting on the same physiological.